Amphiregulin (AREG) (NM_001657) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha) . The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Synonyms
AR; AREGB; CRDGF; SDGF
Gene ID
374
UniProt
P15514
Accession Number mRNA
NM_001657
Chromosomal Location
4q13.3
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
ErbB signaling pathway
Field of Research
ErbB signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Transmembrane
Molecular Weight
55.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
AREG
Species
Human
Protein ID
NP_001648
Overview
Purified recombinant protein of Human amphiregulin (AREG), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/374
Uniprot URL
https://www.uniprot.org/uniprot/P15514
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001657
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001648
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