Cathepsin D (CTSD) (NM_001909) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

Overview

Purified recombinant protein of Human cathepsin D (CTSD), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

CLN10; CPSD; HEL-S-130P

Gene ID

1509

UniProt

P07339, V9HWI3

Accession Number mRNA

NM_001909

Chromosomal Location

11p15.5

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Lysosome

Field of Research

Lysosome

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Protease

Molecular Weight

72.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.