Cathepsin D (CTSD) (NM_001909) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]
Synonyms
CLN10; CPSD; HEL-S-130P
Gene ID
1509
UniProt
P07339, V9HWI3
Accession Number mRNA
NM_001909
Chromosomal Location
11p15.5
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Lysosome
Field of Research
Lysosome
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Protease
Molecular Weight
72.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CTSD
Species
Human
Protein ID
NP_001900
Overview
Purified recombinant protein of Human cathepsin D (CTSD), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1509
Uniprot URL
https://www.uniprot.org/uniprot/P07339
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001909
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001900
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