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DLX3 (NM_005220) Human Recombinant Protein

Product Specifications

Background

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human distal-less homeobox 3 (DLX3), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

AI4; TDO

Gene ID

1747

UniProt

O60479

Accession Number mRNA

NM_005220

Chromosomal Location

17q21.33

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Transcription Factors

Molecular Weight

59.6 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DLX3

Species

Human

Protein ID

NP_005211

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1747

Uniprot URL

https://www.uniprot.org/uniprot/O60479

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005220

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005211

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