C14orf172 (TRMT61A) (NM_152307) Human Recombinant Protein
Product Specifications
Background
Catalytic subunit of tRNA (adenine-N (1) -) -methyltransferase, which catalyzes the formation of N (1) -methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508) . Catalytic subunit of mRNA N (1) -methyltransferase complex, which mediates methylation of adenosine residues at the N (1) position of a small subset of mRNAs: N (1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297) .[UniProtKB/Swiss-Prot Function]
Synonyms
C14orf172; GCD14; Gcd14p; hTRM61; TRM61
Gene ID
115708
UniProt
Q96FX7, A0A024R6Q2
Accession Number mRNA
NM_152307
Chromosomal Location
14q32.33
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome
Molecular Weight
31.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TRMT61A
Species
Human
Protein ID
NP_689520
Overview
Purified recombinant protein of Human tRNA methyltransferase 61 homolog A (S. cerevisiae) (TRMT61A), full length, with N-terminal HIS tag, expressed in E.coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/115708
Uniprot URL
https://www.uniprot.org/uniprot/Q96FX7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_152307
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_689520
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