MITF (NM_000248) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]
Overview
Purified recombinant protein of Human microphthalmia-associated transcription factor (MITF), transcript variant 4, full length, with N-terminal HIS tag, expressed in E.coli, 50ug
Synonyms
BHLHe32; CMM8; COMMAD; MI; WS2; WS2A
Gene ID
4286
UniProt
O75030
Accession Number mRNA
NM_000248
Chromosomal Location
3p13
Expression System
E. coli
Tag
N-His
Related Pathways
Melanogenesis, Melanoma, Pathways in cancer
Field of Research
Melanogenesis, Melanoma, Pathways in cancer
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Transcription Factors
Molecular Weight
46.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MITF
Species
Human
Protein ID
NP_000239
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4286
Uniprot URL
https://www.uniprot.org/uniprot/O75030
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000248
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000239
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