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EED (NM_152991) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human embryonic ectoderm development (EED), transcript variant 2, full length, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

COGIS; HEED; WAIT1

Gene ID

8726

UniProt

O75530

Accession Number mRNA

NM_152991

Chromosomal Location

11q14.2

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

Function

Druggable Genome, Transcription Factors

Molecular Weight

45.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

EED

Species

Human

Protein ID

NP_694536

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8726

Uniprot URL

https://www.uniprot.org/uniprot/O75530

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_152991

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_694536

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