HIST1H2AK (HIST1H2AM) (NM_003514) Human Recombinant Protein
Product Specifications
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Synonyms
DJ193B12.1; H2A.1; H2A/n; H2AC11; H2AC13; H2AC15; H2AC16; H2AFN; HIST1H2AM
Gene ID
8336
UniProt
P0C0S8, A4FTV9
Accession Number mRNA
NM_003514
Chromosomal Location
6p22.1
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Systemic lupus erythematosus
Field of Research
Systemic lupus erythematosus
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.
Molecular Weight
41.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
HIST1H2AM
Species
Human
Protein ID
NP_003505
Overview
Purified recombinant protein of Human histone cluster 1, H2am (HIST1H2AM), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8336
Uniprot URL
https://www.uniprot.org/uniprot/P0C0S8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003514
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003505
Curated Selection
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