N-Myc (MYCN) (NM_005378) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Overview

Purified recombinant protein of Human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MycN), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

BHLHe37; MODED; N-myc; NMYC; ODED

Gene ID

4613

UniProt

P04198

Accession Number mRNA

NM_005378

Chromosomal Location

2p24.3

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

Function

Druggable Genome, Transcription Factors

Molecular Weight

77.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.