N-Myc (MYCN) (NM_005378) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Synonyms
BHLHe37; MODED; N-myc; NMYC; ODED
Gene ID
4613
UniProt
P04198
Accession Number mRNA
NM_005378
Chromosomal Location
2p24.3
Expression System
E. coli
Tag
N-GST and C-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.
Function
Druggable Genome, Transcription Factors
Molecular Weight
77.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
MYCN
Species
Human
Protein ID
NP_005369
Overview
Purified recombinant protein of Human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MycN), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4613
Uniprot URL
https://www.uniprot.org/uniprot/P04198
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_005378
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_005369
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