IRAK (IRAK1) (NM_001569) Human Recombinant Protein
Product Specifications
Background
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human interleukin-1 receptor-associated kinase 1 (IRAK1), transcript variant 1, full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug
Synonyms
IRAK; pelle
Gene ID
3654
UniProt
P51617
Accession Number mRNA
NM_001569
Chromosomal Location
Xq28
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
Field of Research
Apoptosis, Neurotrophin signaling pathway, Toll-like receptor signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.
Function
Druggable Genome, Protein Kinase, Transcription Factors
Molecular Weight
104.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IRAK1
Species
Human
Protein ID
NP_001560
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3654
Uniprot URL
https://www.uniprot.org/uniprot/P51617
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001569
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001560
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