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H2BC10 (NM_003525) Human Recombinant Protein

Product Specifications

Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. The protein has antibacterial and antifungal antimicrobial activity. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Overview

Purified recombinant protein of Human histone cluster 1, H2bi (HIST1H2BI), full length, with N-terminal GST and C-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

H2B/k; H2BC4; H2BC6; H2BC7; H2BC8; H2BFK; HIST1H2BI

Gene ID

8346

UniProt

P62807, B2R4S9

Accession Number mRNA

NM_003525

Chromosomal Location

6p22.2

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Systemic lupus erythematosus

Field of Research

Systemic lupus erythematosus

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1%Sarkosyl.

Molecular Weight

41.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

H2BC10

Species

Human

Protein ID

NP_003516

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/8346

Uniprot URL

https://www.uniprot.org/uniprot/P62807

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_003525

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_003516

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