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IKK alpha (CHUK) (NM_001278) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human conserved helix-loop-helix ubiquitous kinase (CHUK), full length, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

BPS2; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16

Gene ID

1147

UniProt

O15111

Accession Number mRNA

NM_001278

Chromosomal Location

10q24.31

Expression System

E. coli

Tag

N-His

Related Pathways

Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Field of Research

Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome, Protein Kinase

Molecular Weight

84.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CHUK

Species

Human

Protein ID

NP_001269

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1147

Uniprot URL

https://www.uniprot.org/uniprot/O15111

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001278

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001269

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