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NDUFS7 (NM_024407) Human Recombinant Protein

Product Specifications

Background

This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH) :ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (NDUFS7), nuclear gene encoding mitochondrial protein, full length, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

CI-20; CI-20KD; MC1DN3; MY017; PSST

Gene ID

374291

UniProt

O75251, Q7LD69

Accession Number mRNA

NM_024407

Chromosomal Location

19p13.3

Expression System

E. coli

Tag

N-His

Related Pathways

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Field of Research

Alzheimer's disease, Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Molecular Weight

23.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

NDUFS7

Species

Human

Protein ID

NP_077718

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/374291

Uniprot URL

https://www.uniprot.org/uniprot/O75251

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_024407

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_077718

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