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PPIL5 (LRR1) (NM_203467) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene contains a leucine-rich repeat (LRR) . It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Overview

Purified recombinant protein of Human leucine rich repeat protein 1 (LRR1), transcript variant 3, full length, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

4-1BBLRR; LRR-1; PPIL5

Gene ID

122769

UniProt

Q96L50, A0A384MTQ0, Q6AWA7

Accession Number mRNA

NM_203467

Chromosomal Location

14q21.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome

Molecular Weight

16.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

LRR1

Species

Human

Protein ID

NP_982292

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/122769

Uniprot URL

https://www.uniprot.org/uniprot/Q96L50

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_203467

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_982292

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