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CRSP9 (MED7) (NM_001100816) Human Recombinant Protein

Product Specifications

Background

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human mediator complex subunit 7 (MED7), transcript variant 1, full length, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

ARC34; CRSP9; CRSP33

Gene ID

9443

UniProt

O43513, Q6IAZ5

Accession Number mRNA

NM_001100816

Chromosomal Location

5q33.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome, Transcription Factors

Molecular Weight

27.1 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

MED7

Species

Human

Protein ID

NP_001094286

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/9443

Uniprot URL

https://www.uniprot.org/uniprot/O43513

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001100816

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001094286

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