TMEM100 (NM_018286) Human Recombinant Protein
Product Specifications
Background
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.[UniProtKB/Swiss-Prot Function]
Synonyms
FLJ10970; FLJ37856
Gene ID
55273
UniProt
Q9NV29
Accession Number mRNA
NM_018286
Chromosomal Location
17q22
Expression System
E. coli
Tag
N-GST and C-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, pH8.0, 8M Urea.
Function
Transmembrane
Molecular Weight
42.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TMEM100
Species
Human
Protein ID
NP_060756
Overview
Purified recombinant protein of Human transmembrane protein 100 (TMEM100), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/55273
Uniprot URL
https://www.uniprot.org/uniprot/Q9NV29
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_018286
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_060756
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