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APLP1 (NM_001024807) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human amyloid beta (A4) precursor-like protein 1 (APLP1), transcript variant 1, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

APLP

Gene ID

333

UniProt

P51693

Accession Number mRNA

NM_001024807

Chromosomal Location

19q13.12

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome, Transmembrane

Molecular Weight

96.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

APLP1

Species

Human

Protein ID

NP_001019978

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/333

Uniprot URL

https://www.uniprot.org/uniprot/P51693

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001024807

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001019978

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