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OPCML (NM_002545) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Overview

Purified recombinant protein of Human opioid binding protein/cell adhesion molecule-like (OPCML), transcript variant 1, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

IGLON1; OBCAM; OPCM

Gene ID

4978

UniProt

Q14982, A8K0Y0

Accession Number mRNA

NM_002545

Chromosomal Location

11q25

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, pH8.0, 8M Urea.

Function

Druggable Genome, Transmembrane

Molecular Weight

62.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

OPCML

Species

Human

Protein ID

NP_002536

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/4978

Uniprot URL

https://www.uniprot.org/uniprot/Q14982

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_002545

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_002536

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