CDC42 binding protein kinase alpha (CDC42BPA) (NM_014826) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK) . This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

Overview

Purified recombinant protein of Human CDC42 binding protein kinase alpha (DMPK-like) (CDC42BPA), transcript variant A, Ser1419-Pro1638, with N-terminal HIS tag, expressed in E. coli, 50ug

Synonyms

MRCK; MRCKA; PK428

Gene ID

8476

UniProt

Q5VT25

Accession Number mRNA

NM_014826

Chromosomal Location

1q42.13

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol

Function

Druggable Genome, Protein Kinase

Molecular Weight

30 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.