CDC42 binding protein kinase alpha (CDC42BPA) (NM_014826) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK) . This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]
Synonyms
MRCK; MRCKA; PK428
Gene ID
8476
UniProt
Q5VT25
Accession Number mRNA
NM_014826
Chromosomal Location
1q42.13
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol
Function
Druggable Genome, Protein Kinase
Molecular Weight
30 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
CDC42BPA
Species
Human
Protein ID
NP_055641
Overview
Purified recombinant protein of Human CDC42 binding protein kinase alpha (DMPK-like) (CDC42BPA), transcript variant A, Ser1419-Pro1638, with N-terminal HIS tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8476
Uniprot URL
https://www.uniprot.org/uniprot/Q5VT25
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014826
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055641
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