Topoisomerase I (TOP1) (NM_003286) Human Recombinant Protein
Selected Variant
PH30523E1
Size: 50 µg
Product Specifications
Background
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human topoisomerase (DNA) I (TOP1), Lys93-Lys151, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Synonyms
TOPI
Gene ID
7150
UniProt
P11387, Q9BVT2
Accession Number mRNA
NM_003286
Chromosomal Location
20q12
Expression System
E. coli
Tag
N-His-ABP
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol
Function
Druggable Genome
Molecular Weight
21.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TOP1
Species
Human
Protein ID
NP_003277
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7150
Uniprot URL
https://www.uniprot.org/uniprot/P11387
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003286
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003277
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