ACVRL1 (NM_000020) Human Recombinant Protein
Product Specifications
Background
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]
Synonyms
ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I
Gene ID
94
UniProt
P37023, A0A0S2Z310
Accession Number mRNA
NM_000020
Chromosomal Location
12q13.13
Expression System
E. coli
Tag
N-His-ABP
Related Pathways
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
Field of Research
Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol
Function
Druggable Genome, Protein Kinase, Transmembrane
Molecular Weight
25.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ACVRL1
Species
Human
Protein ID
NP_000011
Overview
Purified recombinant protein of Human activin A receptor type II-like 1 (ACVRL1), transcript variant 1, Asp22-Leu119, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/94
Uniprot URL
https://www.uniprot.org/uniprot/P37023
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000020
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000011
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