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ACVRL1 (NM_000020) Human Recombinant Protein

Product Specifications

Background

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human activin A receptor type II-like 1 (ACVRL1), transcript variant 1, Asp22-Leu119, with N-terminal His-ABP tag, expressed in E. coli, 50ug

Synonyms

ACVRLK1; ALK-1; ALK1; HHT; HHT2; ORW2; SKR3; TSR-I

Gene ID

94

UniProt

P37023, A0A0S2Z310

Accession Number mRNA

NM_000020

Chromosomal Location

12q13.13

Expression System

E. coli

Tag

N-His-ABP

Related Pathways

Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol

Function

Druggable Genome, Protein Kinase, Transmembrane

Molecular Weight

25.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

ACVRL1

Species

Human

Protein ID

NP_000011

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/94

Uniprot URL

https://www.uniprot.org/uniprot/P37023

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000020

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000011

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