Porimin (TMEM123) (NM_052932) Human Recombinant Protein
Product Specifications
Background
This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]
Synonyms
KCT3; PORIMIN; PORMIN
Gene ID
114908
UniProt
Q8N131
Accession Number mRNA
NM_052932
Chromosomal Location
11q22.2
Expression System
E. coli
Tag
N-GST, C-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1%Sarkosyl
Function
Transmembrane
Molecular Weight
47 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TMEM123
Species
Human
Protein ID
NP_443164
Overview
Purified recombinant protein of Human transmembrane protein 123 (TMEM123), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/114908
Uniprot URL
https://www.uniprot.org/uniprot/Q8N131
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_052932
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_443164
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