TREM2 (NM_018965) Human Recombinant Protein

Product Specifications

Background

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) . Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Overview

Purified recombinant protein of Human triggering receptor expressed on myeloid cells 2 (TREM2), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c

Gene ID

54209

UniProt

Q9NZC2, Q5TCX1

Accession Number mRNA

NM_018965

Chromosomal Location

6p21.1

Expression System

E. coli

Tag

N-GST and C-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Secreted Protein, Transmembrane

Molecular Weight

51.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.