GADD45B (NM_015675) Human Recombinant Protein
Product Specifications
Background
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Synonyms
GADD45BETA; MYD118
Gene ID
4616
UniProt
O75293
Accession Number mRNA
NM_015675
Chromosomal Location
19p13.3
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Cell cycle, MAPK signaling pathway, p53 signaling pathway
Field of Research
Cell cycle, MAPK signaling pathway, p53 signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome
Molecular Weight
45.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
GADD45B
Species
Human
Protein ID
NP_056490
Overview
Purified recombinant protein of Human growth arrest and DNA-damage-inducible, beta (GADD45B), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4616
Uniprot URL
https://www.uniprot.org/uniprot/O75293
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_015675
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_056490
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