LIN28B (NM_001004317) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Synonyms
CSDD2
Gene ID
389421
UniProt
Q6ZN17
Accession Number mRNA
NM_001004317
Chromosomal Location
6q16.3-q21
Expression System
E. coli
Tag
N-GST and C-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Molecular Weight
54.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
LIN28B
Species
Human
Protein ID
NP_001004317
Overview
Purified recombinant protein of Human lin-28 homolog B (C. elegans) (LIN28B), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/389421
Uniprot URL
https://www.uniprot.org/uniprot/Q6ZN17
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001004317
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001004317
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