ULBP1 (NM_025218) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Overview

Purified recombinant protein of Human UL16 binding protein 1 (ULBP1), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Synonyms

N2DL-1; NKG2DL1; RAET1I

Gene ID

80329

UniProt

Q9BZM6

Accession Number mRNA

NM_025218

Chromosomal Location

6q25.1

Expression System

E. coli

Tag

N-GST and C-His

Related Pathways

Natural killer cell mediated cytotoxicity

Field of Research

Natural killer cell mediated cytotoxicity

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Transmembrane

Molecular Weight

55.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.