ULBP1 (NM_025218) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Synonyms
N2DL-1; NKG2DL1; RAET1I
Gene ID
80329
UniProt
Q9BZM6
Accession Number mRNA
NM_025218
Chromosomal Location
6q25.1
Expression System
E. coli
Tag
N-GST and C-His
Related Pathways
Natural killer cell mediated cytotoxicity
Field of Research
Natural killer cell mediated cytotoxicity
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Transmembrane
Molecular Weight
55.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
ULBP1
Species
Human
Protein ID
NP_079494
Overview
Purified recombinant protein of Human UL16 binding protein 1 (ULBP1), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/80329
Uniprot URL
https://www.uniprot.org/uniprot/Q9BZM6
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_025218
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_079494
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