TYK2 (NM_003331) Human Recombinant Protein
Product Specifications
Background
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also a component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with Immunodeficiency 35. [provided by RefSeq, Sep 2020]
Overview
Purified recombinant protein of Human tyrosine kinase 2 (TYK2), Arg240-Val387, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Synonyms
IMD35; JTK1
Gene ID
7297
UniProt
P29597, A0A024R7E4
Accession Number mRNA
NM_003331
Chromosomal Location
19p13.2
Expression System
E. coli
Tag
N-His-ABP
Related Pathways
Jak-STAT signaling pathway
Field of Research
Jak-STAT signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.
Function
Druggable Genome, Protein Kinase
Molecular Weight
31.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
TYK2
Species
Human
Protein ID
NP_003322
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7297
Uniprot URL
https://www.uniprot.org/uniprot/P29597
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_003331
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_003322
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