PKR (EIF2AK2) (NM_001135651) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Overview
Purified recombinant protein of Human eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), transcript variant 2, Glu51-Asn191, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Synonyms
EIF2AK1; LEUDEN; PKR; PPP1R83; PRKR
Gene ID
5610
UniProt
P19525, Q8IW76
Accession Number mRNA
NM_001135651
Chromosomal Location
2p22.2
Expression System
E. coli
Tag
N-His-ABP
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.
Function
Druggable Genome, Protein Kinase, Transcription Factors
Molecular Weight
30.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EIF2AK2
Species
Human
Protein ID
NP_001129123
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5610
Uniprot URL
https://www.uniprot.org/uniprot/P19525
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001135651
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001129123
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