What is the catalog number for APC (NM_001127511) Human Recombinant Protein?

The catalog number for APC (NM_001127511) Human Recombinant Protein is PH30455E1.

What sizes are available for APC (NM_001127511) Human Recombinant Protein?

APC (NM_001127511) Human Recombinant Protein is available in the following size(s): 50 µg.

Is APC (NM_001127511) Human Recombinant Protein in stock?

APC (NM_001127511) Human Recombinant Protein is currently made to order / not held in immediate stock. Contact us for lead time.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

APC (NM_001127511) Human Recombinant Protein

Selected Variant

PH30455E1

Size: 50 µg

Product Specifications

Background

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Dec 2019]

Overview

Purified recombinant protein of Human adenomatous polyposis coli (APC), transcript variant 1, Glu955-Leu1382, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

BTPS2; DESMD; DP2; DP2.5; DP3; GS; PPP1R46

Gene ID

324

UniProt

P25054, Q4LE70

Accession Number mRNA

NM_001127511

Chromosomal Location

5q22.2

Expression System

E. coli

Tag

N-His

Related Pathways

Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway

Field of Research

Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Function

Druggable Genome

Molecular Weight

47.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

APC

Species

Human

Protein ID

NP_001120983

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/324

Uniprot URL

https://www.uniprot.org/uniprot/P25054

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001127511

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001120983

Price

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) (TYRP1/3280), CF647 conjugate, 0.1mg/mL

BNC473280-100 1x 100 µL