Eotaxin (CCL11) (NM_002986) Human Recombinant Protein

Product Specifications

Background

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Overview

Purified recombinant protein of Human chemokine (C-C motif) ligand 11 (CCL11), Gly24-Pro97, with N-terminal His-Trx tag, expressed in E. coli, 50ug

Synonyms

SCYA11

Gene ID

6356

UniProt

P51671, Q6I9T4

Accession Number mRNA

NM_002986

Chromosomal Location

17q12

Expression System

E. coli

Tag

N-His-Trx

Related Pathways

Asthma, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Field of Research

Asthma, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol.

Function

Druggable Genome, Secreted Protein, Transmembrane

Molecular Weight

28.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.