EIF4EBP1 (NM_004095) Human Recombinant Protein
Product Specifications
Background
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Synonyms
4E-BP1; 4EBP1; BP-1; PHAS-I
Gene ID
1978
UniProt
Q13541
Accession Number mRNA
NM_004095
Chromosomal Location
8p11.23
Expression System
E. coli
Tag
N-His
Related Pathways
Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway
Field of Research
Acute myeloid leukemia, ErbB signaling pathway, Insulin signaling pathway, mTOR signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Molecular Weight
12.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
EIF4EBP1
Species
Human
Protein ID
NP_004086
Overview
Purified recombinant protein of Human eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1), Ser2-Ile118, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1978
Uniprot URL
https://www.uniprot.org/uniprot/Q13541
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004095
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004086
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