P95 NBS1 (NBN) (NM_002485) Human Recombinant Protein

Product Specifications

Background

Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

AT-V1; AT-V2; ATV; NBS; NBS1; P95

Gene ID

4683

UniProt

O60934

Accession Number mRNA

NM_002485

Chromosomal Location

8q21.3

Expression System

E. coli

Tag

N-His

Related Pathways

Homologous recombination

Field of Research

Homologous recombination

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome

Molecular Weight

34 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.