P95 NBS1 (NBN) (NM_002485) Human Recombinant Protein
Product Specifications
Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]
Synonyms
AT-V1; AT-V2; ATV; NBS; NBS1; P95
Gene ID
4683
UniProt
O60934
Accession Number mRNA
NM_002485
Chromosomal Location
8q21.3
Expression System
E. coli
Tag
N-His
Related Pathways
Homologous recombination
Field of Research
Homologous recombination
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome
Molecular Weight
34 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
NBN
Species
Human
Protein ID
NP_002476
Overview
Purified recombinant protein of Human nibrin (NBN), Pro461-Arg754, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/4683
Uniprot URL
https://www.uniprot.org/uniprot/O60934
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002485
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002476
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