Upstream Binding Protein 1 (UBP1) (NM_014517) Human Recombinant Protein
Product Specifications
Background
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity) . Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.[UniProtKB/Swiss-Prot Function]
Synonyms
LBP-1a; LBP-1B; LBP1A; LBP1B
Gene ID
7342
UniProt
Q9NZI7
Accession Number mRNA
NM_014517
Chromosomal Location
3p22.3
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Transcription Factors
Molecular Weight
25.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
UBP1
Species
Human
Protein ID
NP_055332
Overview
Purified recombinant protein of Human upstream binding protein 1 (LBP-1a) (UBP1), transcript variant 1, Lys47-Thr269, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/7342
Uniprot URL
https://www.uniprot.org/uniprot/Q9NZI7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_014517
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_055332
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