Upstream Binding Protein 1 (UBP1) (NM_014517) Human Recombinant Protein

Product Specifications

Background

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity) . Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Human upstream binding protein 1 (LBP-1a) (UBP1), transcript variant 1, Lys47-Thr269, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

LBP-1a; LBP-1B; LBP1A; LBP1B

Gene ID

7342

UniProt

Q9NZI7

Accession Number mRNA

NM_014517

Chromosomal Location

3p22.3

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Transcription Factors

Molecular Weight

25.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.