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WNK1 (NM_213655) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]

Overview

Purified recombinant protein of Human WNK lysine deficient protein kinase 1 (WNK1), transcript variant 3, Thr104-Ala373, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

HSAN2; HSN2; KDP; p65; PPP1R167; PRKWNK1; PSK

Gene ID

65125

UniProt

Q9H4A3

Accession Number mRNA

NM_213655

Chromosomal Location

12p13.33

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Protein Kinase

Molecular Weight

29.2 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

WNK1

Species

Human

Protein ID

NP_998820

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/65125

Uniprot URL

https://www.uniprot.org/uniprot/Q9H4A3

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_213655

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_998820

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