BRCC45 (BRE) (NM_199191) Human Recombinant Protein
Product Specifications
Background
This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]
Synonyms
BRCC4; BRCC45; BRE
Gene ID
9577
UniProt
Q9NXR7
Accession Number mRNA
NM_199191
Chromosomal Location
2p23.2
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome
Molecular Weight
26.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
BABAM2
Species
Human
Protein ID
NP_954661
Overview
Purified recombinant protein of Human brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE), transcript variant 3, Met1-Ala234, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/9577
Uniprot URL
https://www.uniprot.org/uniprot/Q9NXR7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_199191
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_954661
Curated Selection
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