BRCC45 (BRE) (NM_199191) Human Recombinant Protein

Product Specifications

Background

This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]

Overview

Purified recombinant protein of Human brain and reproductive organ-expressed (TNFRSF1A modulator) (BRE), transcript variant 3, Met1-Ala234, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

BRCC4; BRCC45; BRE

Gene ID

9577

UniProt

Q9NXR7

Accession Number mRNA

NM_199191

Chromosomal Location

2p23.2

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome

Molecular Weight

26.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.