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IGFBP3 (NM_001013398) Human Recombinant Protein

Product Specifications

Background

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, Gly28-Lys297, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

BP-53; IBP3

Gene ID

3486

UniProt

P17936

Accession Number mRNA

NM_001013398

Chromosomal Location

7p12.3

Expression System

E. coli

Tag

N-His

Related Pathways

P53 signaling pathway

Field of Research

P53 signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Secreted Protein

Molecular Weight

29.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

IGFBP3

Species

Human

Protein ID

NP_001013416

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3486

Uniprot URL

https://www.uniprot.org/uniprot/P17936

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_001013398

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_001013416

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