IGFBP3 (NM_001013398) Human Recombinant Protein
Product Specifications
Background
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Synonyms
BP-53; IBP3
Gene ID
3486
UniProt
P17936
Accession Number mRNA
NM_001013398
Chromosomal Location
7p12.3
Expression System
E. coli
Tag
N-His
Related Pathways
P53 signaling pathway
Field of Research
P53 signaling pathway
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Function
Druggable Genome, Secreted Protein
Molecular Weight
29.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
IGFBP3
Species
Human
Protein ID
NP_001013416
Overview
Purified recombinant protein of Human insulin-like growth factor binding protein 3 (IGFBP3), transcript variant 1, Gly28-Lys297, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3486
Uniprot URL
https://www.uniprot.org/uniprot/P17936
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_001013398
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_001013416
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