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Kv2.1 (KCNB1) (NM_004975) Human Recombinant Protein

Product Specifications

Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human potassium voltage-gated channel, Shab-related subfamily, member 1 (KCNB1), Gln509-Cys813, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

DEE26; DRK1; Kv2.1

Gene ID

3745

UniProt

Q14721

Accession Number mRNA

NM_004975

Chromosomal Location

20q13.13

Expression System

E. coli

Tag

N-His

Related Pathways

Taste transduction

Field of Research

Taste transduction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.

Function

Druggable Genome, Ion Channels: Potassium, Transmembrane

Molecular Weight

32.7 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

KCNB1

Species

Human

Protein ID

NP_004966

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/3745

Uniprot URL

https://www.uniprot.org/uniprot/Q14721

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_004975

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_004966

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