IFNAR1 (NM_000629) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]

Overview

Purified recombinant protein of Human interferon (alpha, beta and omega) receptor 1 (IFNAR1), Lys276-Asn416, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC

Gene ID

3454

UniProt

P17181

Accession Number mRNA

NM_000629

Chromosomal Location

21q22.11

Expression System

E. coli

Tag

N-His

Related Pathways

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway

Field of Research

Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, Toll-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, Transmembrane

Molecular Weight

16.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.