KCNN4 (NM_002250) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Synonyms
DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; SK4
Gene ID
3783
UniProt
O15554
Accession Number mRNA
NM_002250
Chromosomal Location
19q13.31
Expression System
E. coli
Tag
N-His-ABP
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome, Ion Channels: Potassium, Transmembrane
Molecular Weight
22.4 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
KCNN4
Species
Human
Protein ID
NP_002241
Overview
Purified recombinant protein of Human potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4), Phe301-Lys360, with N-terminal His-ABP tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/3783
Uniprot URL
https://www.uniprot.org/uniprot/O15554
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002250
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002241
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