KCNN4 (NM_002250) Human Recombinant Protein

Product Specifications

Background

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4), Phe301-Lys360, with N-terminal His-ABP tag, expressed in E. coli, 50ug

Synonyms

DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; KCa3.1; KCA4; SK4

Gene ID

3783

UniProt

O15554

Accession Number mRNA

NM_002250

Chromosomal Location

19q13.31

Expression System

E. coli

Tag

N-His-ABP

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, Ion Channels: Potassium, Transmembrane

Molecular Weight

22.4 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.