Coilin (COIL) (NM_004645) Human Recombinant Protein
Product Specifications
Background
The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies) . Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14. [provided by RefSeq, Jul 2008]
Synonyms
CLN80; p80-coilin
Gene ID
8161
UniProt
P38432
Accession Number mRNA
NM_004645
Chromosomal Location
17q22
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Stem cell - Pluripotency
Molecular Weight
24.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
COIL
Species
Human
Protein ID
NP_004636
Overview
Purified recombinant protein of Human coilin (COIL), Met1-Lys220, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/8161
Uniprot URL
https://www.uniprot.org/uniprot/P38432
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_004645
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_004636
Curated Selection
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