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FANCC (NM_000136) Human Recombinant Protein

Product Specifications

Background

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human Fanconi anemia, complementation group C (FANCC), Met1-Ala284, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

FA3; FAC; FACC

Gene ID

2176

UniProt

Q00597, A0A024R9N2

Accession Number mRNA

NM_000136

Chromosomal Location

9q22.32

Expression System

E. coli

Tag

N-His

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome

Molecular Weight

32.5 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

FANCC

Species

Human

Protein ID

NP_000127

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/2176

Uniprot URL

https://www.uniprot.org/uniprot/Q00597

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000136

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000127

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