FANCC (NM_000136) Human Recombinant Protein
Product Specifications
Background
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2) . The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Synonyms
FA3; FAC; FACC
Gene ID
2176
UniProt
Q00597, A0A024R9N2
Accession Number mRNA
NM_000136
Chromosomal Location
9q22.32
Expression System
E. coli
Tag
N-His
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome
Molecular Weight
32.5 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
FANCC
Species
Human
Protein ID
NP_000127
Overview
Purified recombinant protein of Human Fanconi anemia, complementation group C (FANCC), Met1-Ala284, with N-terminal His tag, expressed in E. coli, 50ug
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/2176
Uniprot URL
https://www.uniprot.org/uniprot/Q00597
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000136
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000127
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