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CYP1B1 (NM_000104) Human Recombinant Protein

Product Specifications

Background

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), Leu40-Ala305, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

ASGD6; CP1B; CYPIB1; GLC3A; P4501B1

Gene ID

1545

UniProt

Q16678, Q53TK1

Accession Number mRNA

NM_000104

Chromosomal Location

2p22.2

Expression System

E. coli

Tag

N-His

Related Pathways

Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

Field of Research

Metabolism of xenobiotics by cytochrome P450, Tryptophan metabolism

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, P450

Molecular Weight

30 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CYP1B1

Species

Human

Protein ID

NP_000095

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1545

Uniprot URL

https://www.uniprot.org/uniprot/Q16678

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000104

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000095

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