Dopamine D2 Receptor (DRD2) (NM_000795) Human Recombinant Protein
Product Specifications
Background
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Overview
Purified recombinant protein of Human dopamine receptor D2 (DRD2), transcript variant 1, Ile214-Gln373, with N-terminal His tag, expressed in E. coli, 50ug
Synonyms
D2DR; D2R
Gene ID
1813
UniProt
P14416, A0A024R3C5
Accession Number mRNA
NM_000795
Chromosomal Location
11q23.2
Expression System
E. coli
Tag
N-His
Related Pathways
Gap junction, Neuroactive ligand-receptor interaction
Field of Research
Gap junction, Neuroactive ligand-receptor interaction
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0.
Function
Druggable Genome, GPCR, Transmembrane
Molecular Weight
18.3 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
DRD2
Species
Human
Protein ID
NP_000786
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/1813
Uniprot URL
https://www.uniprot.org/uniprot/P14416
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_000795
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_000786
Frequently Asked Questions
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