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Dopamine D2 Receptor (DRD2) (NM_000795) Human Recombinant Protein

Product Specifications

Background

This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]

Overview

Purified recombinant protein of Human dopamine receptor D2 (DRD2), transcript variant 1, Ile214-Gln373, with N-terminal His tag, expressed in E. coli, 50ug

Synonyms

D2DR; D2R

Gene ID

1813

UniProt

P14416, A0A024R3C5

Accession Number mRNA

NM_000795

Chromosomal Location

11q23.2

Expression System

E. coli

Tag

N-His

Related Pathways

Gap junction, Neuroactive ligand-receptor interaction

Field of Research

Gap junction, Neuroactive ligand-receptor interaction

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

50mM Tris, 8M Urea, pH8.0.

Function

Druggable Genome, GPCR, Transmembrane

Molecular Weight

18.3 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

DRD2

Species

Human

Protein ID

NP_000786

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/1813

Uniprot URL

https://www.uniprot.org/uniprot/P14416

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_000795

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_000786

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