POLD1 (NM_002691) Human Recombinant Protein
Selected Variant
PH30328E1
Size: 50 µg
Product Specifications
Background
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]
Overview
Purified recombinant protein of Human polymerase (DNA directed), delta 1, catalytic subunit 125kDa (POLD1), Arg850-end, with N-terminal His tag, expressed in E. coli, 50ug
Synonyms
CDC2; CRCS10; MDPL; POLD
Gene ID
5424
UniProt
P28340, A0A024R4F4, Q59FA0
Accession Number mRNA
NM_002691
Chromosomal Location
19q13.33
Expression System
E. coli
Tag
N-His
Related Pathways
Base excision repair, DNA replication, Homologous recombination, Metabolic pathways, Mismatch repair, Nucleotide excision repair, Purine metabolism, Pyrimidine metabolism
Field of Research
Base excision repair, DNA replication, Homologous recombination, Metabolic pathways, Mismatch repair, Nucleotide excision repair, Purine metabolism, Pyrimidine metabolism
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
50mM Tris, 8M Urea, pH8.0
Function
Druggable Genome, Stem cell - Pluripotency
Molecular Weight
29.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
POLD1
Species
Human
Protein ID
NP_002682
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/5424
Uniprot URL
https://www.uniprot.org/uniprot/P28340
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_002691
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_002682
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