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MCP2 (CCL8) (NM_005623) Human Recombinant Protein

Product Specifications

Background

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Overview

Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8), esidues 24-99aa, with C-terminal DDK tag, expressed in human cells.

Synonyms

HC14; MCP-2; MCP2; SCYA8; SCYA10

Gene ID

6355

UniProt

P80075

Accession Number mRNA

NM_005623

Chromosomal Location

17q12

Expression System

HEK293

Tag

C-DDK

Related Pathways

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Field of Research

Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 90% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

PBS, pH7.4, 10% glycerol

Function

Druggable Genome, Secreted Protein

Molecular Weight

9.9 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

CCL8

Species

Human

Protein ID

NP_005614

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/6355

Uniprot URL

https://www.uniprot.org/uniprot/P80075

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/NM_005623

Protein ID Link

https://www.ncbi.nlm.nih.gov/nuccore/NP_005614

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