Recombinant Human TNFRSF10B Protein (C-His Tag)
Receptor for the cytotoxic ligand TNFSF10/TRAIL . The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Product Specifications
Purity
Greater than 95% by SDS-PAGE
Form
Lyophilized
Buffer
0.2 μm filtered PBS, pH7.4
Storage Conditions
-70°C
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