[KO Validated] GCN1L1 Rabbit pAb (APR29522N)
Product Specifications
Background
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1 on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality [KO Validated] GCN1L1 Rabbit pAb (APR24523N1) .
Synonyms
GCN1; GCN1L; GCN1L1; PRIC295
Gene ID
10985
UniProt
Q92616
Dilution
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 292kDa Observed MW: 275KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10985
Uniprot URL
https://www.uniprot.org/uniprot/Q92616
AA Sequence
Email for sequence
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6010018-01 0.2 mL
SPACA5B, NT (SPACA5, LYZL5, SPACA5A, Sperm acrosome-associated protein 5, Lysozyme-like protein 5, Sperm-specific lysozyme-like protein X)
Ask
View Details 
MBS6010018-02 5x 0.2 mL
SPACA5B, NT (SPACA5, LYZL5, SPACA5A, Sperm acrosome-associated protein 5, Lysozyme-like protein 5, Sperm-specific lysozyme-like protein X)
Ask
View Details 303381 100 µg
IKK beta, CT (I kappa B Kinase 2, I kappa B Kinase beta, I-kappa-B Kinase 2, I-kappa-B-kinase beta, IkBKB, IKK 2, IKK B, IKK beta, IKK-B, IKK-beta, IKK2, IKKB, IKKB_HUMAN, Inhibitor of kappa Light Chain Gene Enhancer in B Cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B Cells, Inhibitor of kappa Light Polypeptide Gene Enhancer in B Cells Kinase beta, Inhibitor of kappa Light Polypeptide Gene Enhancer in B Cells Kinase beta, Inhibitor of Nuclear Factor kappa B Kinase beta Subunit, Inhibitor of Nuclear Factor kappa B Kinase Subunit beta, Inhibitor of Nuclear Factor kappa-B Kinase Subunit beta, NFKBIKB, Nuclear Factor NF kappa B Inhibitor Kinase beta, Nuclear Factor NF-kappa-B Inhibitor Kinase beta, Nuclear Factor of kappa Light Chain Gene Enhancer in B Cells Inhibitor)
Ask
View Details