SARM1 Rabbit pAb (APR28994N)
Product Specifications
Background
NAD (+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD (+ metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD (+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD (+ into ADP-D-ribose (ADPR, cyclic ADPR (cADPR and nicotinamide; NAD (+ cleavage promoting cytoskeletal degradation and axon destruction. Also able to hydrolyze NADP (+, but not other NAD (+-related molecules. Can activate neuronal cell death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity. Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
Synonyms
SARM; HsTIR; SAMD2; hSARM1; MyD88-5
Gene ID
23098
UniProt
Q6SZW1
Dilution
WB 1:500 - 1:2000 IP 1:50 - 1:200
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 79kDa Observed MW: 73KDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SARM1 Rabbit pAb (APR24581N6) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23098
Uniprot URL
https://www.uniprot.org/uniprot/Q6SZW1
AA Sequence
Email for sequence
Available Sizes
Curated Selection
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