Glucokinase (GCK) Rabbit pAb (APR28841N)
Product Specifications
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI) .
Synonyms
GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
Gene ID
2645
UniProt
P35557
Cellular Locus
Cytoplasm, Nucleus
Applications
WB (Mus musculus, Homo sapiens, Rattus norvegicus)
Dilution
WB 1:500 - 1:2000 IF 1:50 - 1:100
Form
Liquid
Buffer
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Molecular Weight
Calculated MW: 52kDa Observed MW: 52kDa
Storage Conditions
Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Glucokinase (GCK) Rabbit pAb (APR28841N) .
Gene ID URL
https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2645
Uniprot URL
https://www.uniprot.org/uniprot/P35557
AA Sequence
MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS2166305-01 0.1 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details 
MBS2166305-02 0.2 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details 
MBS2166305-03 0.5 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details MBS2166305-04 1 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details MBS2166305-05 5 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details MBS2166305-06 5x 5 mL
Cy3-Linked Monoclonal Antibody to Heart-type Fatty Acid Binding Protein (H-FABP)
Ask
View Details